Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL

Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL.

Humanin (HN) is a recently identified endogenous peptide that protects cells against cytotoxicity induced by various stimuli. Recently, we showed that HN binds to and inhibits Bax, a proapoptotic Bcl-2 family protein, suggesting a mechanism for HN action. In this study, we identified Bim, a Bcl-2 homology 3-only member of the Bcl-2/Bax family, as an additional HN target protein. Using in vitro ...

The Proapoptotic Bcl-2 Family Member Bim

Humanin, a Cytoprotective Peptide, Is Expressed in Carotid Artherosclerotic Plaques in Humans

OBJECTIVE The mechanism of atherosclerotic plaque progression leading to instability, rupture, and ischemic manifestation involves oxidative stress and apoptosis. Humanin (HN) is a newly emerging endogenously expressed cytoprotective peptide. Our goal was to determine the presence and localization of HN in carotid atherosclerotic plaques. METHODS AND RESULTS Plaque specimens from 34 patients ...

Bcl - 2 binds to and inhibits ryanodine receptors 1

Tim Vervliet, Elke Decrock, Jordi Molgó, Vincenzo Sorrentino, Ludwig Missiaen, Luc 2 Leybaert, Humbert De Smedt, Nael Nadif Kasri, Jan B. Parys, Geert Bultynck 3 4 Affiliations 5 1 KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and 6 Molecular Medicine, B-3000 Leuven, Belgium 7 2 University of Ghent, Physiology Group, Department Basic Medical Sciences, B-9000 ...

Bcl-2 binds to and inhibits ryanodine receptors.

The anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein not only counteracts apoptosis at the mitochondria by scaffolding pro-apoptotic Bcl-2-family members, but also acts at the endoplasmic reticulum, thereby controlling intracellular Ca(2+) dynamics. Bcl-2 inhibits Ca(2+) release by targeting the inositol 1,4,5-trisphosphate receptor (IP3R). Sequence analysis has revealed that the Bcl-2-binding ...